Publications
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60. Ho PP, Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, BenBarrak MJ, Hueber W, Steinman L, Robinson WH. Autoimmunity against fibrinogen mediates inflammatory arthritis in mice. J. Immunology, in press.
59. Sharif SA, Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL. Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Arthritis Rheum. 60(10):2902-12, 2009. Download PDF file.
58. Swansan CD, Lindstrom TM, Paniagua RT, Robinson WH. Tyrosine kinases as targets for the treatment of rheumatoid arthritis. Nature Reviews Rheumatology, 5(6):317-24, 2009. Download PDF file.
57. Hueber W, Tomooka BH, Batliwalla F, Li W, Monach PA, Tibshirani RJ, Van Vollenhoven RF, Lampa J, Saito K, Tanaka Y, Genovese MC, Klareskog L, Gregersen PK, Robinson WH. Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis. Arthritis Res Ther. 11(3):R76, 2009. Download PDF file.
56. Monach PA, Hueber W, Kessler B, Tomooka BH, Benbarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C. A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci U S A. 106(37):15867-72, 2009. Download PDF file.
55. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci U S A. 106(29):12145-50, 2009. Download PDF file.
54. Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW, Sagi Y, Davis RE, Staudt LM, Sharman JP, Robinson WH, Levy S. Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. J Cell Sci. 122(Pt 17):3137-44, 2009. Download PDF file.
53. Small TN, Robinson WH, Miklos DB. B cells and transplantation: an educational resource. Biol Blood Marrow Transplant. 15(1 Suppl):104-13, 2009. Download PDF file.
52. Chung L, Fiorentino DF, BenBarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH. Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis & Rheumatism, 60(2):584-591, 2009. Download PDF file.
51. Li H, Chen W, Zhou Y, Abidi P, Sharpe O, Robinson WH, Kraemer FB, Liu J. Identification of mRNA-binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements. J Lipid Res. 50(5):820-31, 2009. Download PDF file.
50. Kidd BA, Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH. Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. Arthritis Res Ther. 2008; 10(5):R119. Download PDF file.
49. Zhao X, Okeke NL, Sharpe O, Batliwalla FM, Lee AT, Ho PP, Tomooka BH, Gregersen PK, Robinson WH. Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. Arthritis Res Ther. 2008; 10(4):R94. Download PDF file.
48. Leung LL, Myles T, Nishimura T, Song JJ, Robinson WH. Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Mol Immunol. 2008; 45(16):4080-4083. Download PDF file.
47. Shachaf CM, Gentles AJ, Elchuri S, Sahoo D, Soen Y, Sharpe O, Perez OD, Chang M, Mitchel D, Robinson WH, Dill D, Nolan GP, Plevritis SK, Felsher DW. Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res. 2008; 68(13):5132-5142. Download PDF file.
46. Romero-Sánchez C, WH Robinson, BH Tomooka, J Londoño, R Valle-Oñate, F Huang, X Deng, L Zhang, C Yang, DT Yu. Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis. Clin Rheumatol 2008; 27(11):1429-1435. Download PDF file.
45. Garren H, Robinson WH, Krasulová E, Havrdová E, Nadj C, Selmaj K, Losy J, Nadj I, Radue EW, Kidd BA, Gianettoni J, Tersini K, Utz PJ, Valone F, Steinman L; BHT-3009 Study Group. Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis. Ann Neurol. 2008; 63(5):611-20. Download PDF file.
44. Hill JA, Bell DA, Brintnell W, Yue D, Wehrli B, Jevnikar AM, Lee DM, Hueber W, Robinson WH, Cairns E. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med. 2008; 205(4):967-79. Download PDF file
43. Kuhn KA, Cozine CL, Tomooka B, Robinson WH, Holers VM. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Mol Immunol. 2008; 45(10):2808-19. Download PDF file.
42. Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 2008; 451(7182):1076-81. Download PDF file.
41. Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007; 13(11):1359-62. Download PDF file.
40. Bar-Or A, Vollmer T, Antel J, Arnold DL,Bodner CA, Campagnolo D, Gianettoni J, Jalili F,Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi F-D, Utz PJ, Valone F, Weiner L, Steinman L, Garren H. Induction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization With DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controlled Phase 1/2 Trial. Arch. Neurol. 2007; 64:E1-E9. Download PDF file.
39. Ousman, SS, Tomooka, BH, van Noort JM, Wawrousek EF, O’Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Protective and therapeutic role for αΒ-crystallin in autoimmune demyelination. Nature. 2007; 448:474-479. Download PDF file.
38. Elchuri S, Naeemuddin M, Sharpe O, Robinson WH, Huang TT. Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice. Proteomics. 2007; 2121-2129.
37. Paniagua PT, Robinson WH. Imatinib for the treatment of rheumatic diseases. Nature Clinical Practice Rheumatology. 2007; 3(4)190-191. Download PDF file.
36. O’Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafle DA, Wucherpfennik KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine. 2007; 13:211-217. Download PDF file.
35. Hueber, W, Tomooka, BH, Zhao, X, Kidd, BA, Drijfhout, JW, Fries, JF, van Venrooij, WJ, Metzger, AL, Genovese, MC, Robinson, WH. Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines. Ann Rheum Dis. 2007; 66:712–719. Download PDF File.
34. Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH. Tolerizing DNA vaccines for autoimmune arthritis. Autoimmunity. 2006; 39:675-82. Download PDF file.
33. Lopez-Avila V, Sharpe O, Robinson WH. Determination of Ceruloplasmin in Human Serum by SEC-ICPMS. Anal Bioanal Chem. 2006; 386:180-187. Download PDF file.
32. Paniagua RT, Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH. J Clin Invest. 2006; 116:2633-2642. Download PDF file.
31. Hueber W, Robinson WH. Proteomic Biomarkers for Autoimmune Disease. Proteomics. 2006; 6:4100-4105. Download PDF file.
30. Kuhn, KA, Lulik L, Tomooka B, Brashler KJ, Arend WP, Robinson WH, Holers VM. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J. Clin. Invest. 2006;116:961-73. Download PDF file
29. Robinson, WH. Antigen arrays for antibody profiling, Curr. Opin. Chem. Biol. 2006;10:67-72. Download PDF file.
28. Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH. Lipid microarrays identify key mediators of autoimmune brain inflammation. Nat. Med. 2006;12:138-143. Download PDF file.
27. Steinman L, Utz PJ, Robinson WH. Suppression of autoimmunity via microbial mimics of altered peptide ligands. Curr Top Microbiol Immunol. 2005;296:55-63. Download PDF file.
26. Platten M, Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, Gupta R, Lee LY, Kidd BA, Robinson WH, Sobel RA, Selley ML, Steinman L. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science. 2005, 310:850-5. Download PDF file.
25. Ho PP, Fontoura P, Platten M, Sobel RA, DeVoss JJ, Lee LY, Kidd BA, Tomooka BH, Capers J, Agrawal A, Gupta R, Zernik J, Yee MK, Lee BJ, Garren H, Robinson WH, Steinman L. A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol. 2005, 175(9):6226-34. Download PDF file.
24. Vossenaar ER, Robinson WH. Citrullination and autoimmune disease: 8th Bertine Koperberg meeting. Ann Rheum Dis. 2005, 64(10):1513-5. Download PDF file.
23. Hueber W, Kidd BA, Tomooka BH, Lee BJ, Bruce B, Fries JF, Sonderstrup G, Monach P, Drijfhout JW, van Venrooij WJ, Utz PJ, Genovese MC, Robinson WH. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2005, 52(9):2645-55. Download PDF file.
22. Fontoura P, Ho PP, DeVoss J, Zheng B, Lee BJ, Kidd BA, Garren H, Sobel RA, Robinson WH, Tessier-Lavigne M, Steinman L. Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol. 2004 Dec 1;173(11):6981-92. Download PDF file.
21. Magnano MD, Robinson WH, Genovese, MC. Demyelination and inhibition of tumor necrosis factor (TNF). Clinical and Experimental Rheumatology. 2004. S134-S140. Download PDF file.
20. Graham KL, Robinson WH, Steinman L, Utz PJ. High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. Autoimmunity. 2004, 37(4):269-72. Review. Download PDF file.
19. Hueber W, Zeng D, Sharpe O, Robinson WH, Strober S, Utz PJ. Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. Eur J Immunol. 2004, 34(6): 1654-62. Download PDF file.
18. Neuman De Vegvar HE, Robinson WH. Microarray profiling of antiviral antibodies for the development of diagnostics, vaccines, and therapeutics. Clin Immunol. 2004, 111(2):196-201. Download PDF file.
17. Utz PJ, Genovese MC, Robinson WH. Unlocking the "PAD" lock on rheumatoid arthritis. Ann Rheum Dis. 2004, 63(4):330-2. Download PDF file.
16. Hueber W, Utz PJ, Robinson WH. Autoantibodies in early arthritis: advances in diagnosis and prognostication. Clin Exp Rheumatol. 2003, 21(5 Suppl 21): S59-64. Review. Download PDF file.
15. Robinson WH, Utz PJ, Steinman L. Genomic and proteomic analysis of multiple sclerosis. Opinion. Curr Opin Immunol. 2003, 15(6):660-7. Download PDF file.
14. Robinson WH, Steinman L, Utz PJ. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics. 2003, 3(11):2077-84. Download PDF file.
13. Neuman De Vegvar HE, Amara RR, Steinman L, Utz PJ, Robinson HL, Robinson WH. Microarray Profiling of Antibody Responses against Simian-Human Immunodeficiency Virus: Postchallenge Convergence of Reactivities Independent of Host Histocompatibility Type and Vaccine Regimen. J Virol. 2003, 15;77(20):11125-11138. Download PDF file.
12. Robinson WH, Fontoura P, Lee BJ, De Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, Van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003, 21(9):1033-1039. Download PDF file.
11. Robinson WH, Steinman L, Utz PJ. Protein and peptide array analysis of autoimmune disease. Biotechniques. 2002, Suppl:66-9. Review. Download PDF file.
10. Hueber W, Utz PJ, Steinman L, Robinson WH. Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res. 2002, 4(5):290-5. Review. Download PDF file.
9. Robinson WH, Steinman L, Utz PJ. Proteomics technologies for the study of autoimmune disease. Arthritis Rheum. 2002, 46(4):885-93. Download PDF file.
8. Robinson WH, Garren H, Utz PJ, Steinman L. Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Clin Immunol. 2002, 103(1):7-12. Review. Download PDF file.
7. Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 2002, 8(3):295-301. Download PDF file.
6. Robinson WH, Genovese MC, Moreland LW. Demyelinating and neurologic events reported in association with tumor necrosis factor alpha antagonism: by what mechanisms could tumor necrosis factor alpha antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? Arthritis Rheum. 2001, 44(9):1977-83. Download PDF file.
5. Robinson WH, Landolfi MM, Parnes JR. Allele-specific expression of the mouse B-cell surface protein CD72 on T cells. Immunogenetics. 1997;45(3):195-200. Download PDF file.
4. Robinson WH, Prohaska SS, Santoro JC, Robinson HL, Parnes JR. Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. J Immunol. 1995, 155(10):4739-48. Download PDF file.
4. Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR. Human CD6 possesses a large, alternatively spliced cytoplasmic domain. Eur J Immunol. 1995, 25(10):2765-9. Download PDF file.
3. Ying H, Nakayama E, Robinson WH, Parnes JR. Structure of the mouse CD72 (Lyb-2) gene and its alternatively spliced transcripts. J Immunol. 1995, 154(6):2743-52. Download PDF file.
2. Robinson WH, Landolfi MM, Schafer H, Parnes JR. Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. J Immunol. 1993, 151(9):4764-72. Download PDF file.
1. Robinson WH, Ying H, Miceli MC, Parnes JR. Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992, 149(3):880-6. Download PDF file.
Book Chapters
4. Utz PJ, Steinman L, Robinson WH. Protein microarrays for analysis of antibody responses in animals and humans. In M. Schena et al. (eds.) Protein Microarrays. Jones and Bartlett Publishers, Boston, Massachusetts. 2004.
3. Genovese MC, and Robinson WH. Modern Therapies for Rheumatoid Arthritis. In G. Tsokos et al. (eds.) Modern Therapeutics for Rheumatoid Diseases. The Humana Press, Inc. Totowa, New Jersey, 2001.
2. Genovese MC, and Robinson WH. Emerging Therapies in Rheumatoid Arthritis. In L. Moreland (ed.) Rheumatoid Arthritis: State of the Art. Remidica, Ltd. London. ReMEDICA Publishing, London, p. 97-114, 2001.
1. Robinson WH, Tutt-Landolfi MM, and Parnes JR. CD72 Workshop Panel Report. In S.F. Schlossman et al. (eds.): Leukocyte Typing V: White Cell Differentiation Antigens. Oxford University Press, Oxford, p. 559-562, 1995.
